Source: CTD_mouse

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1241
Gene Symbol: LTB4R
LTB4R
CUI: C0027719
Disease: Nephrosclerosis
Nephrosclerosis 		0.200 Biomarker CTD_mouse Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. 30818366

2019
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.700 Biomarker CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.600 Biomarker CTD_mouse Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. 29438700

2018
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune 		0.590 Biomarker CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703

2018
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0001925
Disease: Albuminuria
Albuminuria 		0.500 Biomarker CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703

2018
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0342302
Disease: Brittle diabetes
Brittle diabetes 		0.500 Biomarker CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.500 Biomarker CTD_mouse Low-level overexpression of p53 promotes warfarin-induced calcification of porcine aortic valve interstitial cells by activating Slug gene transcription. 29358327

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0876994
Disease: Cardiotoxicity
Cardiotoxicity 		0.500 Biomarker CTD_mouse In this study, the role of p53 in TP-induced cardiotoxicity was investigated in H9c2 cells, primary cardiomyocytes, and C57BL/6 genetic background p53<sup>-/-</sup> mice. p53 protein level was elevated by TP in vitro and in acute heart injury models. 30009776

2018
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C3837958
Disease: Diabetes Mellitus, Ketosis-Prone
Diabetes Mellitus, Ketosis-Prone 		0.500 Biomarker CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703

2018
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C4554117
Disease: Diabetes Mellitus, Sudden-Onset
Diabetes Mellitus, Sudden-Onset 		0.500 Biomarker CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703

2018
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.340 Biomarker CTD_mouse The long tail of oncogenic drivers in prostate cancer. 29610475

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0887833
Disease: Carcinoma, Pancreatic Ductal
Carcinoma, Pancreatic Ductal 		0.280 Biomarker CTD_mouse MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus. 29844410

2018
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.240 Biomarker CTD_mouse Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2Akita mouse. 30463601

2018
Entrez Id: 100287362
Gene Symbol: PRSS46P
PRSS46P
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.200 Biomarker CTD_mouse A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 29915430

2018
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.200 Biomarker CTD_mouse The long tail of oncogenic drivers in prostate cancer. 29610475

2018
Entrez Id: 100287362
Gene Symbol: PRSS46P
PRSS46P
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 Biomarker CTD_mouse A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 29915430

2018
Entrez Id: 100287362
Gene Symbol: PRSS46P
PRSS46P
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.200 Biomarker CTD_mouse A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 29915430

2018
Entrez Id: 100287362
Gene Symbol: PRSS46P
PRSS46P
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.200 Biomarker CTD_mouse A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 29915430

2018
Entrez Id: 100287362
Gene Symbol: PRSS46P
PRSS46P
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.200 Biomarker CTD_mouse A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 29915430

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.700 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.600 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0013221
Disease: Drug toxicity
Drug toxicity 		0.500 Biomarker CTD_mouse Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics. 28193520

2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0019207
Disease: Hepatoma, Morris
Hepatoma, Morris 		0.500 Biomarker CTD_mouse Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. 28100771

2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0019208
Disease: Hepatoma, Novikoff
Hepatoma, Novikoff 		0.500 Biomarker CTD_mouse Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. 28100771

2017